Cheng He, Ph.D.
Professor and Chairman, Department of Neurobiology, Second Military Medical University
Address: 800 Xiangyin Road, Shanghai 200433, P. R. China
Dr. Cheng He earned his bachelor's degree in Pharmacy from Shanghai Medical University in 1986. He received his Ph.D. in Neurobiology from Second Military Medical University in 1995. He completed his postdoctoral training in the laboratory of Prof. D.E. Logothetis at Mount Sinai School of Medicine in New York. He is currently professor and Chair of Department of Neurobiology at Second Military Medical University. He is also Director of Key Laboratory of Molecular Neurobiology of National Ministry of Education. Dr. He’s group is interested in glial functioning in CNS injury and repair. He has authored over 80 publications in peer-reviewed journals and has been the recipient of numerous awards including the Chang-Jiang Scholar Award.
Three representative publications:
1. Cui Li, Lin Xiao, Xiuyun Liu, Wenjing Yang, Weiran Shen, Chun Hu, Guang Yang, Cheng He*. A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination. Glia 2013, 61:732–749
2. Zhida Su, Jingjing Chen, Yang Qiu, Yimin Yuan, Feng Zhu, Yanling Zhu, Xiujie Liu, Yingyan Pu, Cheng He*. Olfactory ensheathing cells: the primary innate immnuocytes in the olfactory pathway to engulf apoptotic olfactory nerve debris. Glia 2013, 61:490–503.
3. Yan Lu, Xiujie Liu, Jianfeng Zhou, Aijun Huang, Jiazhen Zhou, and Cheng He*. TROY Interacts with Rho Guanine Nucleotide Dissociation Inhibitor (RhoGDIα) to Mediate Nogo-induced Inhibition of Neurite Outgrowth. J Biol Chem 2013, 288（47）: 34276–34286
The central nervous system (CNS) consists of two major cell populations: neurons and glial cells. Glial cells provide functional, structural and metabolic support for neurons. Insults to CNS triggers specific reactions of glial cells, including reactive astrogliosis, activation of microglia and demyelination. All these reactions of glial cells are of critical importance for the progress of neuropathology and repair. Dr. Cheng He’s group is interested in glial functioning in CNS injury and repair, particularly in molecular mechanisms underlying axon regeneration, remyelination and neurogenesis. The long-term goal of his group is to develop therapeutic strategies for improvement of functional recovery after CNS injury.
Awards and Honors:
➢ Chang-Jiang Scholar Award (2007, MOE)).
➢ National Science Award for Outstanding Young Researcher (2003, NSFC)
➢ National Science and Technology Award for Young Scientist (2001, CAST)
1. Yimin Yuan, Feng Zhu, Yingyan Pu, Dan Wang, Aijun Huang, Xin Hu, Shangyao Qin, Xiu Sun, Zhida Su*, Cheng He*. Neuroprotective effects of nitidine against traumatic CNS injury via inhibiting microglia activation. Brain Behav Immun. 2015, 48: 287–300
2. Xiao-Fei Gao, Ji-Feng Feng, Wei Wang, Zheng-Hua Xiang, Xiu-Jie Liu, Chan Zhu, Zong-Xiang Tang, Xin-Zhong Dong, Cheng He*. Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3. Nature Communications 2015; 6:7650; doi: 10.1038/ncomms8650.
3. Zhongwang Yu, Dingya Sun, Jifeng Feng, Weixing Tan, Xue Fang, Ming Zhao, Xiaolin Zhao, Yingyan Pu, Aijun Huang, Zhenghua Xiang, Li Cao*, Cheng He*. MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination. The Journal of Neuroscience 2015, 35(16):6350-6365.
4. Wenjing Yang, Lin Xiao, Cui Li, Xiuyun Liu, Mingdong Liu, Qi Shao, Dan Wang, Aijun Huang, Cheng He*. TIP30 Inhibits Oligodendrocyte Precursor Cell Differentiation via Cytoplasmic Sequestration of Olig1. Glia 2015, 63(4):684–698.
5. Cui Li, Lin Xiao, Xiuyun Liu, Wenjing Yang, Weiran Shen, Chun Hu, Guang Yang, Cheng He*. A functional role of NMDA receptor in regulating the differentiation of oligodendrocyte precursor cells and remyelination. Glia 2013, 61:732–749