Institute of Epilepsy

Home > Research > Institute of Epilepsy > Content

Institute of Epilepsy

Yuping Wang

Yuping Wang
Name:  Yuping Wang
Sex:     Male
Date of Birth:    January 9, 1961
Nationality:    The People's Republic of China
Degree:    MD., Ph.D.
Office Address:    Department of Neurology, Xuanwu Hospital, Capital Medical University, Changchunjie 45, Beijing 100053, P.R.China.  
Present Position:     Chief & Professor, Department of Neurology, Xuanwu Hospital, Capital Medical University
Director, Department of Pediatric Neurology, Xuanwu Hospital, Capital Medical University
Director, Comprehensive Epilepsy Center of Beijing
Director, Sleep Center of Xuanwu Hospital
Ph. D, April 1992- March 1996, Graduate School of Medicine, Tottori University, Yonago, Japan; . Major: Neurology and Neuroscience.
Research Student, Oct. 1991-March 1992,  School of Medicine, Tottori University, Yonago, Japan;
Master of Science (MS), Sep.1983-June 1986,  Hebei Medical University, Shijiazhuang, China,  Major: Neurology and Neurophysiology.
MD equivalent, Medicine, Oct.1978-Aug.1983,  Hebei Medical University, Shijiazhuang, China.
Professor, Dec. 2003 to now, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Associate Professor, Sep. 1998 – Dec. 2003.  Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Visiting Professor, April. 1998 - Aug. 1998.  Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Assistant Professor,  Sep. 1996 - Sep. 1998,  Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Junior Assistant Professor, April 1996- Aug. 1996,  Institute of Neurological Sciences, School of Medicine, Tottori University, Yonago, Japan.
Attending Neurologist, June 1988-Sep.1991, Department of Neurology, Second Affiliated Hospital, Hebei Medical University, China.
Resident, July 1986-June 1988,  Department of Neurology, Second Affiliated Hospital, Hebei Medical University, China.
Research Interests:
Clinical Neurophysiology; Cognitive Neuroscience
1. Cognitive Brain Dynamic Model for Information Internalization
Human brain is one of the most complex systems in the universe.  In human brain, numerous neurons connect with each other, message is communicated between them.  I am interested in cortical brain mapping, using fMRI, magnetoencephalography (MEG), intracranial EEG recording and signal analyzing, transcranial magnetic stmulation, and electrical cortical stimulation to find out the functional representation of any cortex areas. In cooperating with engineers, new electroencephalographical signal and magnetoencephalographic field analyzing algorithms were developed for source localization to construct an integrated dynamic model to explain the basic cognition processes in human brain. Advanced cortical processing model for information internalization is proposed.

2. Non-invasive Brain Stimulation
Non-invasive procedures such as tDCS or rTMS are new techniques for brain stimulation. I am now testing the effects of these techniques in ameliorating symptoms of brain functional disorders. Therapeutic parameters and brain targets have been established for patients with epilepsy, insomnia, RLS, anxiety, ADHD, tics, and central pain. Now I am cooperating with engineers to establish an auto-system for detecting abnormal brain signals, localizing functional disturbance regions, guiding the manipulation of brain modulation procedures.

3. Mechanisms of Epileptic Brain Network Forming and Suppressing
Epilepsy is a brain disorder due to abnormal neuronal synchronization. I employed MEG, TMS-EEG, intracranial EEG with cortical stimulation to tailor the margin of cortical areas involved in a seizure. I am now developing new method to find out how patches of cortical areas are activated simultaneously. Cooperating with engineers, I am now developing a new device for responsive stimulating, which can block the abnormal brain activity propagation in the brain.  The implantation of such a device in specific region of the brain or in a part of body can be an effective therapeutic strategy for epilepsy.

4. Pathophysiological Investigation of Functional Brain Disorders
Functional brain disorders, including sleep disorders, movement disorders, emotional and cognitive disorders are common problems.  I have devoted a lot in studying the pathophysiology of brain of these disorders, investing the involved cortical areas and circuits, testing the unbalance of functional connection.  

Clinical Specialty:
Clinical practice in neurology
Specialty in epilepsy, sleep disorders, cognitive & emotional disorders, movement disorders

Member of Task Force on Clinical Practice Guidelines of International League Against Epilepsy (ILAE)
President, Neurology Society of China International Exchange and Promotive Association for Medical and Health Care (CPAM)
Past president, Chinese Society of Sleep Medicine (CSSM)
Vice president, Chinese EMG and Clinical Neurophysiology Society
Vice president, Chinese Sleep Research Society
Board member, Chinese EEG and Epilepsy Society (CEES)
Vice president, China Association Against Epilepsy (CAAE)
Vice president, EEG Society Branch of China Association Against Epilepsy (CAAE)
Executive director, Chinese Society of Psychosomatic Medicine
Executive director, Chinese Neuro-modulation Society
Member, Chinese Medical Association

Editor or Reviewer:
Editor, Sleep Medicine
Editor of Several Domestic Medicine Journals
Reviewer, Psychophysiology
Reviewer, Int. J. Psychophysiology
Reviewer, Clinical Neurophysiology
Reviewer, Neuroscience Letters

Awards and Honors:
1.    Awards for Science and Technology Advancement by Beijing Municipal Government (2012). Advancement for epilepsy diagnosis and treatment.
2.    The First Class Doctor of Beijing Municipal Health System (2010).
3.    Talented Person Project for New Century by Beijing Municipal Government (2006).
4.    Awards of Wujieping Medical Research (2006).
5.    Awards for Science and Technology Advancement by Beijing Municipal Government (2004). Cognitive potential N270 and cortical origin.
6.    Awards of Chinese Medical Science and Technology by Chinese Medical Association (2004). Cognitive potential N270 and cortical origin.

English Publications

1.    Guo Q, Lin Y, Li L, Zhan S, Liu A, Gao L, Lin H, Yang Y, Wang Y. Paroxysmal dyskinesia on waking: two case reports. Sleep Medicine. in printing.
2.    Wang J; Ning R; Wang Y. Plasma D-dimer level, the promising prognostic biomarker for the acute cerebral infarction patients. Journal of Stroke and Cerebrovascular Diseases. In printing.
3.    Sauro KM, Wiebe S, Dunkley C, Janszky J, Kumlien E, Moshe S, Nakasato N, Pedley TA, Perucca E, Senties H, Thomas SV, Wang Y, Wilmshurst J, Jette N. The current state of epilepsy guidelines: A systematic review. Epilepsia, 2015, in printing.
4.    Mei LP, Li LP, Ye J, Wang YP, Zhao J, Zhang T. A Special Electroencephalography Pattern Might Help in the Diagnosis of Antibody-positive Encephalitis. Chin Med J (Engl). 2015; 128(18): 2474-2477.
5.    Liu C, Dai Z, Zhang R, Zhang M, Hou Y, Qi Z, Huang Z, Lin Y, Zhan S, He Y, Wang Y. Mapping intrinsic functional brain changes and repetitive transcranial magnetic stimulation neuromodulation in idiopathic restless legs syndrome: a resting-state functional magnetic resonance imaging study. Sleep Medicine 2015, 16: 785–791.