Institute of Brain Tumor

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Institute of Brain Tumor

Guanghui Liu

Guanghui Liu
Guanghui Liu, Ph.D, Professor
Education and Research Experience
1997-2002,B.S., Peking University Health Science Center
2002-2007,Ph.D., Institute of Biophysics, Chinese Academy of Sciences
2007-2009,Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute
2009-2011,Research associate, Gene expression laboratory, The Salk Institute for Biological Studies
2011-,Professor, Institute of Biophysics, Chinese Academy of Sciences
Research Interests:
1. Using pluripotent stem cells to study and treat human diseases
2. Genetic and epigenetic basis of healthy aging
Selected publications
1.    Duan S, Yuan G, Liu X, Ren R, Li J, Zhang W, Wu J, Xu X, Fu L, Li Y, Yang J, Zhang W, Bai R, Yi F, Suzuki K, Gao H, Esteban CR, Zhang C, Belmonte JC, Chen Z, Wang X, Jiang T, Qu J#, Tang F#, Liu GH#. PTEN deficiency reprograms human neuralstem cells towards a glioblastoma stem cell-like phenotype. Nat Commun. 2015. 6:10068. (#Corresponding author)
2.    Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J#,Tang F#, Liu GH#.SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016.26(2):190-205. (#Corresponding author)
Highlighted by Cell (DOI:
Highlighted by Cell Res (Cell Res|doi: 10.1038/cr.2016.8)
3.    Guo J, Fang W, Sun L, Lu Y, Dou L, Huang X, Sun M, Qu J#, Liu GH#, Li J#. Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1. Oncotarget. 2016. doi: 10.18632/oncotarget.9183. (#Corresponding author)
4.    Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z.SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507.
5.    .Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH#, Misteli T#, Repression of the antioxidant NRF2 pathway in premature aging. Cell. 2016. 165,1361-1374 (#Corresponding author)
Highlighted by Cell (DOI:
Book chapter:
Liu GH#, Yang J, Ding Z, Ocampo A, Qu J, Suzuki K, Izpisua Belmonte JC#. Chapter: iPSC disease modeling of laminopathies. Human iPS Cells in Disease Modeling (Springer), 2016, pp 53-67 (#Corresponding author)