Institute of Alzheimer disease

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Institute of Alzheimer disease

Chang Chen

Chang Chen
Chang Chen, Ph.D., Professor, Principal Investigator at the Institute of Biophysics, Chinese Academy of Sciences. Vice Director of National Laboratory of Biomacromolecules. Chief Scientist of Chinese Ministry of Science and Technology 973 Program. National Outstanding Young Scientists. Special Government Allowances of the State Council.
Education and Training
1986-1990  B.S., Nankai University, Tianjin, China
1990-1993  M.S., Beijing Normal University, Beijing, China
1993-1996  Ph.D., Peking University, Beijing, China
1996-1998  Assistant Professor, Institute of Biophysics, CAS
1998-2000    Associate Professor, Institute of Biophysics, CAS Visiting Scientist in the Institute of Food Research, Norwich, UK(The Royal Society K.C. Wong Research Fellowship))
2000-Present  Principle Investigator (PI )(2004, full professor. Institute of Biophysics, CAS.
2004-2005  Visiting Scientist, Center for Cancer Research, the Medical Research Council, Cambridge, UK
Professional Society Memberships and Committee Experiences
2013-Present    The Biophysical Society of China, Deputy General Secretary, Standing Committee Member
2013-Present    The Beijing Society of Biochemistry and Molecular Biology, Vice President
2010-Present    The Chinese Society of Biochemistry and Molecular Biology, Council Member
2010-Present    Dissertation Committee, Institute of Biophysics, CAS
2008-2012    Head of Professional Women Association, Institute of Biophysics, CAS
2006-Present    Education Committee, Institute of Biophysics, CAS
2006-Present    Vice President of the Commission for Free Radical Biology and Medicine of the Biophysical Society of China
2006-Present    International Society for Free Radical Research, Council Member of SFRR-Asia
Editorial Board Member: Redox Biology; Free Radical Research.
Associate Editor: Biophysics Reports; Progress in Biochemistry and Biophysics.

Research interests

Reactive oxygen species and reactive nitrogen species (ROS and RNS) have critical biological functions essential for normal physiology. However, overproduction or deficiency result in impaired homeostasis and is associated with pathology, such as ageing-related diseases, neurodegenerative diseases. Our research has been focused on the crosstalk between these small molecules and macromolecules through protein thiol modification, trying to explore the relationship between protein function and cellular redox status. Our current research is focused on the three parts as following: Redox regulation (oxidative/nitrosative stress) in aging and the related diseases; nitric oxide and S-nitros(yl)ation and other thiol modification in cellular quality control; hypoxia and disease and the function of PI4KIIα. We have answered the question about the specificity of the interaction between reactive oxygen/nitrogen species and proteins through thiol modification, and proposed the important physiological role of thiol based redox switch signaling. We have published 58 papers, two book chapters and obtained four patents.

Representative publications:
1.    Qiangjun Zhou, Jiangmei Li, Hang Yu,Yujia Zhai, Zhen Gao, Yanxin Liu, Xiaoyun Pang, Lunfeng Zhang, Klaus Schulten, Fei Sun, and Chang Chen. Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα. Nat. Commun. 2014; 5:35-52.
2.    Wu, K., Ren, R., Su, W., Wen, B., Zhang, Y., Yi, F., Qiao, X., Yuan, T., Wang, J., Liu, G, Chen C.. A Novel Suppressive Effect of Alcohol Dehydrogenase 5 in Neuronal Differentiation. The Journal of biological chemistry 2014; 289, 20193-20199.
3.    Kairui Mao, Shuzhen Chen, Mingkuan Chen, Yonglei Ma, Yan Wang, Bo Huang, Zhengyu He, Yan Zeng, Yu Hu, Shuhui Sun, jing li, Xiaodong Wu, Xiangrui Wang, Warren Strober, Chang Chen, Guangxun Meng, Bing Sun. Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock, Cell Research 2013; (23):201-212.
4.    Hou QL, Jiang HQ, Zhang X, Guo C, Huang B, Wang P, Wang TP, Wu KY, Li J, Gong ZF, Du LB, Liu Y, Liu L, Chen C*(2011). Nitric oxide metabolism controlled by formaldehyde dehydrogenase (fdh, homolog of mammalian GSNOR) plays a crucial role in visual pattern memory in Drosophila. Nitric Oxide-Biology and Chemistry, 24 : 17-24.
5.    Huang B, Chen C* (2010) Detection of Protein S-Nitrosation Using Irreversible Biotinylation Procedures (IBP). Free Radical Biology & Medicine, 49, 447–456.